Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Learn to control your emotions, control your thoughts, get over fear of rejection and learn to open up.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
The Good Place
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
12. Is there something I am clinging to? We don’t always realize when we’re clinging to something harmful when it feels safe and familiar, whether it is an unfulfilling job, an unhealthy relationship, or a stagnant way of life. Recognize if you are clinging to something that isn’t serving you and work on taking small steps towards change and release.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
He also posted a picture of himself looking at a racially diverse group of children.
Trends and targets in antiviral phototherapy
In this April 24, 1984, file photo, from left, Steve Jobs, chairman of Apple Computers, John Sculley, president and CEO, and Steve Wozniak, co-founder of Apple, unveil the new Apple IIc computer in San Francisco
7.Yes, John was with me last night. – Because that’s what friends do… we agree and ask questions later。
The QUBE will remind you to recycle, monitor when the trash was last taken out, and tell you to change the air freshener. These are all things people usually remember to do anyway, by the smell and all, but now there's a $300 "elegant" stainless steel can that'll constantly remind you with annoying mobile alerts.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Federica Mogherini, the EU’s foreign policy chief, and Johannes Hahn, the bloc’s enlargement commissioner, have also weighed in, criticising Mr Erdogan’s proposed constitutional changes and his recent rhetoric.
IMD participants praised the way their training pushed them out of their comfort zones and also the one-on-one coaching sessions tailored to their individual business situations. “It was an eye opener about what a good leader is,” commented one participant. “We learnt about ourselves first, what drives us and why, in order to manage others.”
ACE2 as a potential therapeutic target for pandemic COVID-19
德系三巨头：由于奔驰的几款低价产品不可避免地会损害它“要么最好，要么什么都不是”(the best or nothing)的商誉，该公司也开始陷入低迷。而即将推出的新7系轿车则会进一步巩固宝马在美国富人圈中的地位。另外，起价30,795美元的奥迪A3，很可能会使奥迪的销量较2014年增长15%，新款Q7也将进一步提高奥迪的利润。
Diagnostic technologies for COVID-19: a review
Sam Smith is a fluid soul man, with style channeling Otis Redding, Aretha Franklin and Ray Charles alongside modern icons like Amy Winehouse and Adele.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
About 980 million yuan of illicit assets were recovered, according to the Communist Party of China Central Commission for Discipline Inspection.
Warm hearted wishes for a happy New Year filled with all your favorite things.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
As a result, his position on the Forbes' ranking dropped 220 spots, leaving him tied with 19 others as the 544th richest person in the world.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Snap, however, has sunk to about $15 after initially rallying from its IPO price of $17 in March, damping some expectation of further activity involving so-called decacorns, tech companies that have achieved valuations of $10bn or more through private funding.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Yu Xiuhua, born with cerebral palsy, lived a quiet village life. She is now a literary sensation whose vivid, erotic poems are “stained with blood.”
Antiviral drug discovery: broad-spectrum drugs from nature
He did several makeup tests to get the look that would so dramatically change Mr. Carell. “We were literally creating a new human being,” Mr. Corso said.
But only 14,000 tourists took advantage of the visa-free stopover, according to the Beijing General Station of Exit and Entry Frontier Inspection, well short of the 20,000 target officials had previously predicted.
They need more talent. Full stop. The best avenue for attracting talent for them has always been the draft.
Influenza neuraminidase: A druggable target for natural products
尽管金融行业整体趋势向上，但相较于男性，女老板执掌的企业筹得的资金历来处于落后状态。例如，2013年上半年，寻求融资的企业中，老板是女性的企业仅占16%，而其中又仅有24%的女性接受了天使资金。Plum Alley是一家为女性创业者提供在线商务服务的平台，最近该公司推出了一个专注于帮助女性创新者推进到下一个事业阶段的众筹平台。作为呈现爆炸式增长趋势的众筹领域（预计明年规模将达到39.8亿美元）中的首个此类平台，我们应该能看到Plum Alley在未来一年中在女性创业领域扮演重要角色。
2. Smart water bottle
It might be that bit too far from the mainstream to make a huge awards impact.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The pandas did some tai-chi in Trafalgar Square before kicking on at a panda party in Convent Garden as part of the first ever Panda Awareness Week.
The role of biosensors in the detection of emerging infectious diseases
Elspeth Cheung, head of BrandZ valuation at Millward Brown, says: “The top 10 used to be dominated by consumer goods. This year, it’s technology.”
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Whiteness means being part of the group whose appearance, traditions, religion and even food are the default norm. It’s being a person who, by unspoken rules, was long entitled as part of “us” instead of “them.”
Letizia Battaglia chronicled Palermo’s Mafia wars in the 1970s and ’80s for a local newspaper. Now, her images appear in museums and retrospectives.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Snapchat on Tuesday launched Discover, a section of its app where media outlets including Vice, CNN andPeople magazine can publish video content within Snapchat. Already several of the channels feature ads, which aren’t cheap. According to Adweek, Snapchat ads cost $750,000 per day.
The number of students who will study abroad after graduation has also seen a drop, down from 4.8 percent last year to 3.4 percent.
At tech start-up conferences, such as Slush in Helsinki in December, everyone was talking about experiences. The coming year is likely to see a wider adoption of virtual reality, which places the user in a digitally enhanced environment, and augmented reality, which overlays digital information on to the real world, creating new digital businesses.
At school, even in kindergarten, you teach us to behave in the world. You teach us: not to fight with others, to respect others, to clean up our mess, not to hurt other creatures, to share - not be greedy. 在学校，甚至在幼稚园，你们大人教我们如何处世，你们告诉我们不要打架，要尊重对方。找出答案，解决矛盾。去分享，而不是贪婪。
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
纽约人向专栏提出的问题，不仅取决于他们的个人情况，还取决于当今的重大问题，比如住房成本上升、士绅化、豆腐渣工程。最终，2014年成为了一个一切都在增长的年份，增长的包括房价、租金，以及最重要的——楼盘数量。根据纽约房地产委员会(Real Estate Board of New York)的数据，10月批准建设的单元达到了16700套。
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
The .40-calibre Smith & Wesson that killed her, a semi-automatic handgun, was seized by police to undergo ballistics testing to determine if it had been used in other crimes.
1. glitterati / n . 知名人 士，国际上层社会人士。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Some of the leaked photos and videos can still be found on Chinese social media as of press time.
“Even though I’m an engineer and an analytical person at heart, the most important decisions I’ve ever made had nothing to do with any of that,” he told an interviewer at Duke University, where he studied for an MBA, last year. “They were always based on intuition.”
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
8.A New iPhone
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
不论是在那首一目了然的《IDGAF》（《我才不在乎呢》）中对情人的不屑一顾，还是在那首狂热的《Lost in Your Light》（《迷失在你的光芒中》）与米格尔热烈的音乐相和，她以些许艾蕾莎·贝丝·摩儿那种深沉的态度和些许希雅那种令人受不了的夸张，强烈地表达着自己的情感，但她也是一位比这两人都要热情的歌手。
The worst of 2015
Temperatures in 2015 also shattered the previous record set in 2014 by 0.13C, according to Nasa.
It is just a common sense that no one wants to see chaos at his doorstep.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
It's time to make New Year resolutions for traveling! Backpacker bible Lonely Planet has published its annual list of best value destinations in 2017 for people looking for wallet-friendly sightseeing experiences. Take a look.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
You're the best present I ever received.你是我所收到的最好的礼物。
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
The same seven schools continue to dominate the top half of the ranking. AGSM at UNSW Business School of Australia entered the ranking for the first time in eighth position.
8. Smile every time EXCEPT when my team is losing.
Fluctuations of the markets led to a tightening of IPO approval to maintain stability, according to Frank Lyn, PwC China's mainland and Hong Kong Markets Leaders.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Yes, it is that obvious when you're interviewing elsewhere and go MIA, with or without a flimsy excuse. Schedule phone interviews for personal hours, like a lunch break, and take vacation or PTO days for lengthy in-person interviews. "That way, you're not feeling pressured during the interview to get back to work – which can affect how you handle the interview – and you're not stealing time from your employers," Kay says。
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
9. 安布罗斯·阿钦摩西尔(Ambrose Akinmusire)，《想像中的救世主更容易描绘》(the imagined savior is far easier to paint)，Blue Note。小号手安布罗斯·阿钦摩西尔为自己在Blue Note公司发行的第二张专辑注入了类型不固定，富于探索精神的今日之声，有许多歌手和一支弦乐四重奏组合参与。和这张专辑刚发行的时候相比，如今的他有了更多评论社会的迫切与讥讽时局的精神。
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The .40-calibre Smith & Wesson that killed her, a semi-automatic handgun, was seized by police to undergo ballistics testing to determine if it had been used in other crimes.
Yes — just. Democrats will regain control of the House of Representatives in the November midterm elections. Though they will not take charge until January 2019, they will waste no time preparing the House Judiciary paperwork. Mr Trump will label it a “witch hunt”. But another year of his surreal presidency makes it all but inevitable Democrats will campaign on a pledge to hold him to account. Whatever Robert Mueller’s investigation unearths before then is unlikely to turn enough Republicans against him.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Recipient: Lindsay Lohan
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
When I am creating a light novel, Iam creating it mostly alone. When I am working on anime there is a director andthe staff with a point of view on my works. There usually are several revisionsregarding the storyboard. What is interesting is what will come back. It's avery interesting part of the work.
Attention, travel lovers. You may not have made any travel plans yet, but the choices for next year’s best destinations are already out. Recently, the well-known travel guide publisher Lonely Planet issued its Best in Travel 2014 selection. Here, we pick a few countries from its top 10 list to give you a taste.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
In 2013, the yuan appreciated almost 3% against the U.S. dollar, making 'Beijing a more expensive destination than in the past,' Jiang Yiyi noted.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Stand: Yahoo CEO Marissa Mayer defended work-from-home ban
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
China has become the world's largest industrial robot market since 2013, and currently its domestic suppliers are moving up the supplier chain by offering more high-end products in recent years, added the report.
自2007年4月以来，全球最具价值品牌100强的品牌价值增长106%。同期标准普尔500指数(S&P 500)和MSCI明晟全球指数(MSCI world index)分别上涨61%和21%。
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Paul George, Chris Paul, Carmelo Anthony, Gordon Hayward Jimmy Butler, Derrick Rose, Paul Millsap, J.J. Redick, Eric Bledsoe, Dwight Howard ... the list goes on and on of players who switched uniforms since last year.
Anti-HIV drug repurposing against SARS-CoV-2
The drama got 7.2 points on Douban, receiving criticism for having too much romance and too few of Zhou's struggles.
The data was released to encourage the adoption of stronger passwords. Mr Slain added:"As always, we hope that with more publicity about how risky it is to use weak passwords, more people will start taking simple steps to protect themselves by using stronger passwords and using different passwords for different websites."
在苹果今年6月举行的全球开发者大会(Worldwide Developer Conference)上，库克被应用开发者团团围住，要求与他自拍合影。到了10月的iPad发布会，他甚至自己讲起了笑话。他还是一贯的着装，简单朴实：黑衬衫，牛仔裤，衬衫下摆散着。他说，Apple Watch得到了“深谙时尚与风格——比我还懂的人”的热烈好评，一边说，一边心照不宣地指着轻声发笑的观众。
Length-scale dependence of protein hydration-shell density
Total Program Cost: $98,906
But then the story took a strange turn. Koudijs and Voth found that Dutch lenders reacted to the Seppenwolde collapse in strikingly different ways. Those who had made loans to Seppenwolde but hadn’t actually lost money became far more pessimistic and demanded much bigger haircuts from all new borrowers. But those who had dodged the bullet by not lending to Seppenwolde didn’t tighten their requirements at all. In fact, those lenders slightly reduced haircuts to their borrowers – a sign they were at least as sanguine as before.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Prices at China's factory gates fell for a 34th consecutive month in December, pushed down by falling energy and commodity prices.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
About this collection
In a humiliating 111-77 loss to the Golden State Warriors at Oracle Arena, Bryant shot 1-of-14 from the field, including 1-of-7 from 3-point range, and scored four points. He also shot 1-of-14 in a loss last season to the San Antonio Spurs.
I wish you a happy New Year. All affection and best wish